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9 effects of vitamin B12 deficiency

Posted on January 6, 2026 by Admin

Vitamin B12 (cobalamin) is essential for nerve function, red blood cell production, and DNA synthesis. A deficiency can affect multiple body systems. Here are 9 common effects of vitamin B12 deficiency:


1. Fatigue and Weakness

  • Low B12 reduces red blood cell production, leading to anemia, which causes tiredness, weakness, and lack of energy.

2. Pale or Jaundiced Skin

  • Anemia can make skin appear pale, while red blood cell breakdown can sometimes cause a slightly yellowish (jaundiced) tint.

3. Numbness or Tingling

  • Peripheral neuropathy: B12 is crucial for nerve health, so deficiency may cause pins-and-needles, numbness, or tingling in hands and feet.

4. Difficulty Walking or Balance Issues

  • Nerve damage can affect coordination and balance, sometimes making walking awkward or unstable.

5. Cognitive Problems

  • B12 deficiency can lead to memory loss, difficulty concentrating, or confusion, and in severe cases, mimic dementia.

6. Mood Changes

  • Low B12 is linked to depression, irritability, or anxiety because B12 helps in the production of brain chemicals that regulate mood.

7. Glossitis and Mouth Ulcers

  • The tongue may become swollen, red, or painful (glossitis), and mouth ulcers may appear.

8. Shortness of Breath and Dizziness

  • Anemia reduces oxygen delivery to tissues, causing breathlessness, dizziness, or lightheadedness, especially with activity.

9. Visual Disturbances

  • Rarely, B12 deficiency can damage the optic nerve, leading to blurred vision or vision loss.

💡 Extra Tip: Because B12 deficiency develops slowly, symptoms often appear gradually and may be mistaken for aging, stress, or other conditions.

If you want, I can also make a quick table showing these 9 effects with the underlying cause, which makes it easier to remember for school or health exams. Do you want me to do that?

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